We are the CRISPR Microbiome
Precision killing of bacteria has the impact to revolutionise the management of untreatable and difficult-to-treat infections as well as complex diseases directly impacted by the human microbiota.
Our mission is to develop CRISPR-based medicines that give hope for effective and safe treatment of difficult-to-treat diseases in the future.
$50M Series A Raised
SNIPR Biome raises $50M in one of the largest SERIES A in Europe from 4 large European funds to advance CRISPR-based microbiome drugs to human clinical trials.
Since its inception in August 2017, SNIPR Biome has over the cause of 18 months grown to a team of 18 - predominantly PhDs.
9+ Patent Families
The SNIPR Biome scientists have made 9 innovative and novel discoveries which are being protected in 9 separate patent families – two of which have already granted as US patents (US9701964 and US10195273).
The Gut Microbiome
Trillions of healthy bacteria live inside the human gut. It is estimated that the number of microbes reach 10^12 per gram in the human large intestine (luminal content of the colon) where these bacteria play a crucial role both in physiology and health as well as influence the cause of disease. The gut microbiome performs a number of crucial functions for the host from helping to digest our food, to produce vitamins and priming our immune system to tolerance - thus, these vast numbers of bacteria live in a complex symbioses with their host.
In healthy individuals the human microbiome is dominated by two large Phyla: Bacteroidetes and Firmicutes with smaller representations from Proteobacteria and Actinobacteria. In some cases the body reacts badly to its own bacteria, which can lead to immune stimulation and gut inflammation. There is an increasing understanding that perturbations and large changes in the microbiome (dysbiosis) are associated with human disease and that specifically addressing the human gut microbiome composition can represent an attractive medical and pharmacological avenue.
We aim to be able to make targeted microbiome engineering with our CRISPR-based precision medicines.
We aim to be able to develop CRISPR-based medicines that give hope for effective and safe treatment of difficult-to-treat infections in the future
CRISPR-based drug candidates for difficult-to-treat infections.
CRISPR-based drug candidates for precision microbiome engineering in auto-immune & malignant disorders.
SNIPR BIOME is pioneering a novel use of CRISPR/Cas technology to selectively eradicate target bacteria, while leaving the rest of the patient’s microbial community intact.
We are utilizing the bacteria’s adaptive CRISPR-based immune system in a fully programmable fashion to very selectively kill target bacteria based on specific DNA sequence signatures in the bacterial genome.
SNIPR BIOME has the potential to develop valuable therapeutics within multiple important disease areas, and we have decided to focus initially on novel, narrow-spectrum (or otherwise rationally-tailored) anti-bacterial drug candidates for use in difficult-to-treat infections or precision microbiome modulation for the auto-immunity and oncology/immuno-oncology setting.
CRISPR-based medicines hold the promise to offer very safe medications due to their very high specificity.
Work With Us
SNIPR Biome is the leading CRISPR Microbiome company. As a growing company we are always looking for new talents to join our team in the capital of Denmark, Copenhagen. Our main goal is to engineer microbiomes using CRISPR technology, to treat a number of serious and life-threatening diseases, ranging from IBD, Multi-drug resistant infections to cancer. The working environment is fun, fast-paced, collaborative and outcome focused. If you are curious, smart and passionate about inventing tomorrow’s medicine then drop us a line.
In Vivo Pharmacologist
Are you a skilled In Vivo Pharmacologist? Would you like to be part of a dynamic team to help the company develop new medicines in the microbiome and antibacterial fields?
Are you a skilled Bioinformatician? Would you like to be part of a dynamic team to help SNIPR Biome develop new medicines?
Are you a skilled Lab Technician with experience in molecular biology? Would you like to be part of a dynamic team to help the company develop new medicines?